Regulatory T cells (Tregs) are a subset of T cells with immunosuppressive functions. They secrete IL-10, TGF-âand other suppressive cytokines and direct contact among cells to suppress the autoimmunity response of effector T cells, promote immune tolerance, which has a very important role in maintaining the body’s homeostasis. Foxp3 is a specific transcription factor of Treg cells and plays a key role in the regulation of Treg cell development and function. Treg and Th17 cells are derived from the differentiation of the same type of initial CD4+T cells. The direction of differentiation depends on the type of cytokines in the environment. The functions of them are opposite to each other and transform each other under certain conditions. It plays an important role in inducing immune tolerance and preventing the occurrence of autoimmune diseases (AID). Once immune imbalance, it will lead to the occurrence of immune-related diseases. The decrease of its number or function will affect the immune state of the body, cause disorders of autoimmune tolerance and lead to the occurrence of AID. This article reviews the research of Treg and their cytokines in AID in order to understand the role of Treg in the pathogenesis of AID, and open a new way for the treatment of AID.
| Published in | Science Journal of Public Health (Volume 8, Issue 3) |
| DOI | 10.11648/j.sjph.20200803.14 |
| Page(s) | 83-91 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Regulatory T Cells, Interleukin-10, Transforming Growth Factor-â, Forkhead Box p3, Autoimmune Diseases
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APA Style
Cuicui Wang, Zhaoxin Mu, Zhenjiang Hou. (2020). Research Progress on Regulatory T Cells and Their Relationship with Autoimmune Diseases. Science Journal of Public Health, 8(3), 83-91. https://doi.org/10.11648/j.sjph.20200803.14
ACS Style
Cuicui Wang; Zhaoxin Mu; Zhenjiang Hou. Research Progress on Regulatory T Cells and Their Relationship with Autoimmune Diseases. Sci. J. Public Health 2020, 8(3), 83-91. doi: 10.11648/j.sjph.20200803.14
AMA Style
Cuicui Wang, Zhaoxin Mu, Zhenjiang Hou. Research Progress on Regulatory T Cells and Their Relationship with Autoimmune Diseases. Sci J Public Health. 2020;8(3):83-91. doi: 10.11648/j.sjph.20200803.14
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Download@article{10.11648/j.sjph.20200803.14,
author = {Cuicui Wang and Zhaoxin Mu and Zhenjiang Hou},
title = {Research Progress on Regulatory T Cells and Their Relationship with Autoimmune Diseases},
journal = {Science Journal of Public Health},
volume = {8},
number = {3},
pages = {83-91},
doi = {10.11648/j.sjph.20200803.14},
url = {https://doi.org/10.11648/j.sjph.20200803.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20200803.14},
abstract = {Regulatory T cells (Tregs) are a subset of T cells with immunosuppressive functions. They secrete IL-10, TGF-âand other suppressive cytokines and direct contact among cells to suppress the autoimmunity response of effector T cells, promote immune tolerance, which has a very important role in maintaining the body’s homeostasis. Foxp3 is a specific transcription factor of Treg cells and plays a key role in the regulation of Treg cell development and function. Treg and Th17 cells are derived from the differentiation of the same type of initial CD4+T cells. The direction of differentiation depends on the type of cytokines in the environment. The functions of them are opposite to each other and transform each other under certain conditions. It plays an important role in inducing immune tolerance and preventing the occurrence of autoimmune diseases (AID). Once immune imbalance, it will lead to the occurrence of immune-related diseases. The decrease of its number or function will affect the immune state of the body, cause disorders of autoimmune tolerance and lead to the occurrence of AID. This article reviews the research of Treg and their cytokines in AID in order to understand the role of Treg in the pathogenesis of AID, and open a new way for the treatment of AID.},
year = {2020}
}
TY - JOUR T1 - Research Progress on Regulatory T Cells and Their Relationship with Autoimmune Diseases AU - Cuicui Wang AU - Zhaoxin Mu AU - Zhenjiang Hou Y1 - 2020/06/04 PY - 2020 N1 - https://doi.org/10.11648/j.sjph.20200803.14 DO - 10.11648/j.sjph.20200803.14 T2 - Science Journal of Public Health JF - Science Journal of Public Health JO - Science Journal of Public Health SP - 83 EP - 91 PB - Science Publishing Group SN - 2328-7950 UR - https://doi.org/10.11648/j.sjph.20200803.14 AB - Regulatory T cells (Tregs) are a subset of T cells with immunosuppressive functions. They secrete IL-10, TGF-âand other suppressive cytokines and direct contact among cells to suppress the autoimmunity response of effector T cells, promote immune tolerance, which has a very important role in maintaining the body’s homeostasis. Foxp3 is a specific transcription factor of Treg cells and plays a key role in the regulation of Treg cell development and function. Treg and Th17 cells are derived from the differentiation of the same type of initial CD4+T cells. The direction of differentiation depends on the type of cytokines in the environment. The functions of them are opposite to each other and transform each other under certain conditions. It plays an important role in inducing immune tolerance and preventing the occurrence of autoimmune diseases (AID). Once immune imbalance, it will lead to the occurrence of immune-related diseases. The decrease of its number or function will affect the immune state of the body, cause disorders of autoimmune tolerance and lead to the occurrence of AID. This article reviews the research of Treg and their cytokines in AID in order to understand the role of Treg in the pathogenesis of AID, and open a new way for the treatment of AID. VL - 8 IS - 3 ER -
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