The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy

Jing Zhang; Bo Yang; Haowen Pang; Guangpeng Zhang; Renjin Chen; Lei Li

doi:doi:10.11648/j.sjph.20200802.14

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The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy

Jing Zhang, Bo Yang, Haowen Pang, Guangpeng Zhang, Renjin Chen, Lei Li

Published in Science Journal of Public Health (Volume 8, Issue 2)

Received: 11 April 2020 Accepted: 3 May 2020 Published: 28 May 2020

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Abstract

Purpose: To study the difference of physical dose of target volume and lungs among actual irregular arrangement multi-needle interstitial brachytherapy plan (AIBP), virtual regular arrangement multi-needle interstitial brachytherapy plan (VRBP) and virtual single needle center point interstitial brachytherapy plan (VSBP). Methods: According to the inclusion criteria: the CTV shape was approximately spherical and multiply needles arrangement was irregular. Thirteen lung cancer patients underwent interstitial brachytherapy were collected. Based on the thirteen CT data sets, the AIBP, VRBP and VSBP were respectively designed, then we collected the dose metrics involving: the minimum dosage received by 95% of the CTV (D95), D90, D80, D50 and D30; the percentage of lung volume receiving a dose of ≥ 5 Gy (V5), V20, V30 and the mean lung dose (MLD); D50 of heart; the maximum dose (Dmax) of spinal cord and the Dmax of ribs. The differences were tested by the two-sample paired (Wilcoxon) signed rank test, a P value less than 0.05 was considered statistically significant. Result: The differences of D95, D90, D80, D50 and D30 of CTV, D50 of heart, Dmax of spinal and Dmax of ribs were not statistical significant (P>0.05) and the V5, V20, V30 and MLD of lungs and ipsilateral lung were statistical significant (P<0.05) between AIBP and VRBP. The differences of D95, D90, D80 and D50 of CTV, D50 of heart, Dmax of spinal cord, Dmax of ribs, V5, V20, V30 and MLD of lungs and ipsilateral lung were not statistical significant (P>0.05) except for D30 of CTV (P<0.05) between AIBP and VRBP. Conclusion: In interstitial brachytherapy for lung tumor, the arrangement of implantation needles could influenced the dose distribution in target and lungs. If the CTV shape could be approximately considered to be a spherical and a regular arrangement of multiply needles was difficult to achieve; the lung dose of the AIBP might have no obvious advantage over the VSBP and the VSBP should be worth a try.

Published in	Science Journal of Public Health (Volume 8, Issue 2)
DOI	10.11648/j.sjph.20200802.14
Page(s)	50-55
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Interstitial Brachytherapy, Lung Cancer, Dose Distribution

References

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[14]	Lee A, Supariwala A, Venkat P, et al. Interstitial CT-Guided Lung Brachytherapy [J]. Brachytherapy, 2019, 18 (3): S84-S85.
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[17]	Tselis N, Ferentinos K, Kolotas C, et al. Computed tomography-guided interstitial high-dose-rate brachytherapy in the local treatment of primary and secondary intrathoracic malignancies [J]. Journal of Thoracic Oncology Official Publication of the International Association for the Study of Lung Cancer, 2011, 6 (3): 545.

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APA Style

Jing Zhang, Bo Yang, Haowen Pang, Guangpeng Zhang, Renjin Chen, et al. (2020). The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy. Science Journal of Public Health, 8(2), 50-55. https://doi.org/10.11648/j.sjph.20200802.14

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ACS Style

Jing Zhang; Bo Yang; Haowen Pang; Guangpeng Zhang; Renjin Chen, et al. The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy. Sci. J. Public Health 2020, 8(2), 50-55. doi: 10.11648/j.sjph.20200802.14

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AMA Style

Jing Zhang, Bo Yang, Haowen Pang, Guangpeng Zhang, Renjin Chen, et al. The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy. Sci J Public Health. 2020;8(2):50-55. doi: 10.11648/j.sjph.20200802.14

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@article{10.11648/j.sjph.20200802.14,
  author = {Jing Zhang and Bo Yang and Haowen Pang and Guangpeng Zhang and Renjin Chen and Lei Li},
  title = {The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy},
  journal = {Science Journal of Public Health},
  volume = {8},
  number = {2},
  pages = {50-55},
  doi = {10.11648/j.sjph.20200802.14},
  url = {https://doi.org/10.11648/j.sjph.20200802.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20200802.14},
  abstract = {Purpose: To study the difference of physical dose of target volume and lungs among actual irregular arrangement multi-needle interstitial brachytherapy plan (AIBP), virtual regular arrangement multi-needle interstitial brachytherapy plan (VRBP) and virtual single needle center point interstitial brachytherapy plan (VSBP). Methods: According to the inclusion criteria: the CTV shape was approximately spherical and multiply needles arrangement was irregular. Thirteen lung cancer patients underwent interstitial brachytherapy were collected. Based on the thirteen CT data sets, the AIBP, VRBP and VSBP were respectively designed, then we collected the dose metrics involving: the minimum dosage received by 95% of the CTV (D95), D90, D80, D50 and D30; the percentage of lung volume receiving a dose of ≥ 5 Gy (V5), V20, V30 and the mean lung dose (MLD); D50 of heart; the maximum dose (Dmax) of spinal cord and the Dmax of ribs. The differences were tested by the two-sample paired (Wilcoxon) signed rank test, a P value less than 0.05 was considered statistically significant. Result: The differences of D95, D90, D80, D50 and D30 of CTV, D50 of heart, Dmax of spinal and Dmax of ribs were not statistical significant (P>0.05) and the V5, V20, V30 and MLD of lungs and ipsilateral lung were statistical significant (PP>0.05) except for D30 of CTV (P<0.05) between AIBP and VRBP. Conclusion: In interstitial brachytherapy for lung tumor, the arrangement of implantation needles could influenced the dose distribution in target and lungs. If the CTV shape could be approximately considered to be a spherical and a regular arrangement of multiply needles was difficult to achieve; the lung dose of the AIBP might have no obvious advantage over the VSBP and the VSBP should be worth a try.},
 year = {2020}
}

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TY  - JOUR
T1  - The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy
AU  - Jing Zhang
AU  - Bo Yang
AU  - Haowen Pang
AU  - Guangpeng Zhang
AU  - Renjin Chen
AU  - Lei Li
Y1  - 2020/05/28
PY  - 2020
N1  - https://doi.org/10.11648/j.sjph.20200802.14
DO  - 10.11648/j.sjph.20200802.14
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 50
EP  - 55
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20200802.14
AB  - Purpose: To study the difference of physical dose of target volume and lungs among actual irregular arrangement multi-needle interstitial brachytherapy plan (AIBP), virtual regular arrangement multi-needle interstitial brachytherapy plan (VRBP) and virtual single needle center point interstitial brachytherapy plan (VSBP). Methods: According to the inclusion criteria: the CTV shape was approximately spherical and multiply needles arrangement was irregular. Thirteen lung cancer patients underwent interstitial brachytherapy were collected. Based on the thirteen CT data sets, the AIBP, VRBP and VSBP were respectively designed, then we collected the dose metrics involving: the minimum dosage received by 95% of the CTV (D95), D90, D80, D50 and D30; the percentage of lung volume receiving a dose of ≥ 5 Gy (V5), V20, V30 and the mean lung dose (MLD); D50 of heart; the maximum dose (Dmax) of spinal cord and the Dmax of ribs. The differences were tested by the two-sample paired (Wilcoxon) signed rank test, a P value less than 0.05 was considered statistically significant. Result: The differences of D95, D90, D80, D50 and D30 of CTV, D50 of heart, Dmax of spinal and Dmax of ribs were not statistical significant (P>0.05) and the V5, V20, V30 and MLD of lungs and ipsilateral lung were statistical significant (PP>0.05) except for D30 of CTV (P<0.05) between AIBP and VRBP. Conclusion: In interstitial brachytherapy for lung tumor, the arrangement of implantation needles could influenced the dose distribution in target and lungs. If the CTV shape could be approximately considered to be a spherical and a regular arrangement of multiply needles was difficult to achieve; the lung dose of the AIBP might have no obvious advantage over the VSBP and the VSBP should be worth a try.
VL  - 8
IS  - 2
ER  -

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Author Information

Jing Zhang

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Bo Yang

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Haowen Pang

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Guangpeng Zhang

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Renjin Chen

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Lei Li

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China

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APA Style

Jing Zhang, Bo Yang, Haowen Pang, Guangpeng Zhang, Renjin Chen, et al. (2020). The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy. Science Journal of Public Health, 8(2), 50-55. https://doi.org/10.11648/j.sjph.20200802.14

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ACS Style

Jing Zhang; Bo Yang; Haowen Pang; Guangpeng Zhang; Renjin Chen, et al. The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy. Sci. J. Public Health 2020, 8(2), 50-55. doi: 10.11648/j.sjph.20200802.14

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AMA Style

Jing Zhang, Bo Yang, Haowen Pang, Guangpeng Zhang, Renjin Chen, et al. The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy. Sci J Public Health. 2020;8(2):50-55. doi: 10.11648/j.sjph.20200802.14

Copy | Download

@article{10.11648/j.sjph.20200802.14,
  author = {Jing Zhang and Bo Yang and Haowen Pang and Guangpeng Zhang and Renjin Chen and Lei Li},
  title = {The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy},
  journal = {Science Journal of Public Health},
  volume = {8},
  number = {2},
  pages = {50-55},
  doi = {10.11648/j.sjph.20200802.14},
  url = {https://doi.org/10.11648/j.sjph.20200802.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20200802.14},
  abstract = {Purpose: To study the difference of physical dose of target volume and lungs among actual irregular arrangement multi-needle interstitial brachytherapy plan (AIBP), virtual regular arrangement multi-needle interstitial brachytherapy plan (VRBP) and virtual single needle center point interstitial brachytherapy plan (VSBP). Methods: According to the inclusion criteria: the CTV shape was approximately spherical and multiply needles arrangement was irregular. Thirteen lung cancer patients underwent interstitial brachytherapy were collected. Based on the thirteen CT data sets, the AIBP, VRBP and VSBP were respectively designed, then we collected the dose metrics involving: the minimum dosage received by 95% of the CTV (D95), D90, D80, D50 and D30; the percentage of lung volume receiving a dose of ≥ 5 Gy (V5), V20, V30 and the mean lung dose (MLD); D50 of heart; the maximum dose (Dmax) of spinal cord and the Dmax of ribs. The differences were tested by the two-sample paired (Wilcoxon) signed rank test, a P value less than 0.05 was considered statistically significant. Result: The differences of D95, D90, D80, D50 and D30 of CTV, D50 of heart, Dmax of spinal and Dmax of ribs were not statistical significant (P>0.05) and the V5, V20, V30 and MLD of lungs and ipsilateral lung were statistical significant (PP>0.05) except for D30 of CTV (P<0.05) between AIBP and VRBP. Conclusion: In interstitial brachytherapy for lung tumor, the arrangement of implantation needles could influenced the dose distribution in target and lungs. If the CTV shape could be approximately considered to be a spherical and a regular arrangement of multiply needles was difficult to achieve; the lung dose of the AIBP might have no obvious advantage over the VSBP and the VSBP should be worth a try.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy
AU  - Jing Zhang
AU  - Bo Yang
AU  - Haowen Pang
AU  - Guangpeng Zhang
AU  - Renjin Chen
AU  - Lei Li
Y1  - 2020/05/28
PY  - 2020
N1  - https://doi.org/10.11648/j.sjph.20200802.14
DO  - 10.11648/j.sjph.20200802.14
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 50
EP  - 55
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20200802.14
AB  - Purpose: To study the difference of physical dose of target volume and lungs among actual irregular arrangement multi-needle interstitial brachytherapy plan (AIBP), virtual regular arrangement multi-needle interstitial brachytherapy plan (VRBP) and virtual single needle center point interstitial brachytherapy plan (VSBP). Methods: According to the inclusion criteria: the CTV shape was approximately spherical and multiply needles arrangement was irregular. Thirteen lung cancer patients underwent interstitial brachytherapy were collected. Based on the thirteen CT data sets, the AIBP, VRBP and VSBP were respectively designed, then we collected the dose metrics involving: the minimum dosage received by 95% of the CTV (D95), D90, D80, D50 and D30; the percentage of lung volume receiving a dose of ≥ 5 Gy (V5), V20, V30 and the mean lung dose (MLD); D50 of heart; the maximum dose (Dmax) of spinal cord and the Dmax of ribs. The differences were tested by the two-sample paired (Wilcoxon) signed rank test, a P value less than 0.05 was considered statistically significant. Result: The differences of D95, D90, D80, D50 and D30 of CTV, D50 of heart, Dmax of spinal and Dmax of ribs were not statistical significant (P>0.05) and the V5, V20, V30 and MLD of lungs and ipsilateral lung were statistical significant (PP>0.05) except for D30 of CTV (P<0.05) between AIBP and VRBP. Conclusion: In interstitial brachytherapy for lung tumor, the arrangement of implantation needles could influenced the dose distribution in target and lungs. If the CTV shape could be approximately considered to be a spherical and a regular arrangement of multiply needles was difficult to achieve; the lung dose of the AIBP might have no obvious advantage over the VSBP and the VSBP should be worth a try.
VL  - 8
IS  - 2
ER  -

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