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Ecofriendly Synthesis of Bioactive 2-thiobarbituric Acid Derivatives

Received: 22 February 2017     Accepted: 15 March 2017     Published: 27 March 2017
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Abstract

In this study, five derivatives of 2-thiobarbituric acid were prepared under microwave irradiation (MWI) and conventional heating method. It was found that the preparation time wasreduced from 24 hours to 5-10 minutes by using microwave irradiation method. In microwave irradiation, the yield also comparatively very high (97.50-98.32%) than conventional method (74-78%). FT-IR, 1H-NMR spectral data were used to determine the structures of the compounds. The antimicrobial activity of the synthesized compounds were investigated by using Staphylococcus aureus, Bacillus megaterium, Escherichia coli and Pseudomonas aeruginosa bacteia. The zone of inhibition of the compounds were found in the range of 8 to 14 mm. In cytotoxic analysis, the mortality 74-89% were appeared when sample concentration were (0.78-6.25) μg/ml and more than 6.25 μg/ml concentration showed 100% mortality. The antimicrobial and cytotoxic activity of synthesized compoundswas found due to the presence of a reactive and unsaturated ketone.

Published in International Journal of Bioorganic Chemistry (Volume 2, Issue 3)
DOI 10.11648/j.ijbc.20170203.11
Page(s) 83-86
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Microwave Irradiation (MWI), 2-thiobarbituric Acid Derivatives, Arylidene Acetophenone, Antimicrobial and Cytotoxic Activity

References
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Cite This Article
  • APA Style

    M. A. Sattar, Mst. Khodeza Khatun, Tapan K. Sarkar, Sharif M. Al-Reza. (2017). Ecofriendly Synthesis of Bioactive 2-thiobarbituric Acid Derivatives. International Journal of Bioorganic Chemistry, 2(3), 83-86. https://doi.org/10.11648/j.ijbc.20170203.11

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    ACS Style

    M. A. Sattar; Mst. Khodeza Khatun; Tapan K. Sarkar; Sharif M. Al-Reza. Ecofriendly Synthesis of Bioactive 2-thiobarbituric Acid Derivatives. Int. J. Bioorg. Chem. 2017, 2(3), 83-86. doi: 10.11648/j.ijbc.20170203.11

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    AMA Style

    M. A. Sattar, Mst. Khodeza Khatun, Tapan K. Sarkar, Sharif M. Al-Reza. Ecofriendly Synthesis of Bioactive 2-thiobarbituric Acid Derivatives. Int J Bioorg Chem. 2017;2(3):83-86. doi: 10.11648/j.ijbc.20170203.11

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  • @article{10.11648/j.ijbc.20170203.11,
      author = {M. A. Sattar and Mst. Khodeza Khatun and Tapan K. Sarkar and Sharif M. Al-Reza},
      title = {Ecofriendly Synthesis of Bioactive 2-thiobarbituric Acid Derivatives},
      journal = {International Journal of Bioorganic Chemistry},
      volume = {2},
      number = {3},
      pages = {83-86},
      doi = {10.11648/j.ijbc.20170203.11},
      url = {https://doi.org/10.11648/j.ijbc.20170203.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbc.20170203.11},
      abstract = {In this study, five derivatives of 2-thiobarbituric acid were prepared under microwave irradiation (MWI) and conventional heating method. It was found that the preparation time wasreduced from 24 hours to 5-10 minutes by using microwave irradiation method. In microwave irradiation, the yield also comparatively very high (97.50-98.32%) than conventional method (74-78%). FT-IR, 1H-NMR spectral data were used to determine the structures of the compounds. The antimicrobial activity of the synthesized compounds were investigated by using Staphylococcus aureus, Bacillus megaterium, Escherichia coli and Pseudomonas aeruginosa bacteia. The zone of inhibition of the compounds were found in the range of 8 to 14 mm. In cytotoxic analysis, the mortality 74-89% were appeared when sample concentration were (0.78-6.25) μg/ml and more than 6.25 μg/ml concentration showed 100% mortality. The antimicrobial and cytotoxic activity of synthesized compoundswas found due to the presence of a reactive and unsaturated ketone.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Ecofriendly Synthesis of Bioactive 2-thiobarbituric Acid Derivatives
    AU  - M. A. Sattar
    AU  - Mst. Khodeza Khatun
    AU  - Tapan K. Sarkar
    AU  - Sharif M. Al-Reza
    Y1  - 2017/03/27
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ijbc.20170203.11
    DO  - 10.11648/j.ijbc.20170203.11
    T2  - International Journal of Bioorganic Chemistry
    JF  - International Journal of Bioorganic Chemistry
    JO  - International Journal of Bioorganic Chemistry
    SP  - 83
    EP  - 86
    PB  - Science Publishing Group
    SN  - 2578-9392
    UR  - https://doi.org/10.11648/j.ijbc.20170203.11
    AB  - In this study, five derivatives of 2-thiobarbituric acid were prepared under microwave irradiation (MWI) and conventional heating method. It was found that the preparation time wasreduced from 24 hours to 5-10 minutes by using microwave irradiation method. In microwave irradiation, the yield also comparatively very high (97.50-98.32%) than conventional method (74-78%). FT-IR, 1H-NMR spectral data were used to determine the structures of the compounds. The antimicrobial activity of the synthesized compounds were investigated by using Staphylococcus aureus, Bacillus megaterium, Escherichia coli and Pseudomonas aeruginosa bacteia. The zone of inhibition of the compounds were found in the range of 8 to 14 mm. In cytotoxic analysis, the mortality 74-89% were appeared when sample concentration were (0.78-6.25) μg/ml and more than 6.25 μg/ml concentration showed 100% mortality. The antimicrobial and cytotoxic activity of synthesized compoundswas found due to the presence of a reactive and unsaturated ketone.
    VL  - 2
    IS  - 3
    ER  - 

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Author Information
  • Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia, Bangladesh

  • Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia, Bangladesh

  • Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia, Bangladesh

  • Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia, Bangladesh

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