Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis

Subhashini; Preeti Singh Chauhan; Sharda Kumari; Debabrata Dash; Rashmi Singh

doi:doi:10.11648/j.ajls.20130104.14

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Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis

Subhashini, Preeti Singh Chauhan, Sharda Kumari, Debabrata Dash, Rashmi Singh

Published in American Journal of Life Sciences (Volume 1, Issue 4)

Received: 19 June 2013 Published: 30 July 2013

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Abstract

Curcumin, the active component of turmeric, is a polyphenolic phytochemical with anti-tumor, anti-inflammatory, anti-oxidative and anti-allergic properties. Mast cells participate in allergic inflammation by virtue of their ability of being activated to allergens and lead to the release of number of biologically active mediators including histamine, prostaglandins, leukotrienes, various cytokines etc. In this report, we have investigated effects of curcumin on non-immunological stimulations like Compound 48/80 induced systemic anaphylaxis. In vitro experiments have confirmed non-toxicity of curcumin (50µM) as assessed by MTT test but 100µM dose was found toxic. Curcumin (50µM) inhibited Compound 48/80 induced mouse peritoneal mast cell (MPMC) degranulation and histamine release in dose-dependent manner. Therefore, it is worth to study effect of curcumin on non-immunological stimulations as most often it occurs without IgE involvement. Whether it has mast cell membrane stabilizing activity or some other signaling mechanisms are involved underlying its potential could be explored further.

Published in	American Journal of Life Sciences (Volume 1, Issue 4)
DOI	10.11648/j.ajls.20130104.14
Page(s)	165-170
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Compound 48/80, Curcumin, Histamine, Mast Cells, Systemic Anaphylaxis

References

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APA Style

Subhashini, Preeti Singh Chauhan, Sharda Kumari, Debabrata Dash, Rashmi Singh. (2013). Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis. American Journal of Life Sciences, 1(4), 165-170. https://doi.org/10.11648/j.ajls.20130104.14

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ACS Style

Subhashini; Preeti Singh Chauhan; Sharda Kumari; Debabrata Dash; Rashmi Singh. Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis. Am. J. Life Sci. 2013, 1(4), 165-170. doi: 10.11648/j.ajls.20130104.14

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AMA Style

Subhashini, Preeti Singh Chauhan, Sharda Kumari, Debabrata Dash, Rashmi Singh. Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis. Am J Life Sci. 2013;1(4):165-170. doi: 10.11648/j.ajls.20130104.14

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@article{10.11648/j.ajls.20130104.14,
  author = {Subhashini and Preeti Singh Chauhan and Sharda Kumari and Debabrata Dash and Rashmi Singh},
  title = {Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis},
  journal = {American Journal of Life Sciences},
  volume = {1},
  number = {4},
  pages = {165-170},
  doi = {10.11648/j.ajls.20130104.14},
  url = {https://doi.org/10.11648/j.ajls.20130104.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20130104.14},
  abstract = {Curcumin, the active component of turmeric, is a polyphenolic phytochemical with anti-tumor, anti-inflammatory, anti-oxidative and anti-allergic properties. Mast cells participate in allergic inflammation by virtue of their ability of being activated to allergens and lead to the release of number of biologically active mediators including histamine, prostaglandins, leukotrienes, various cytokines etc. In this report, we have investigated effects of curcumin on non-immunological stimulations like Compound 48/80 induced systemic anaphylaxis. In vitro experiments have confirmed non-toxicity of curcumin (50µM) as assessed by MTT test but 100µM dose was found toxic. Curcumin (50µM) inhibited Compound 48/80 induced mouse peritoneal mast cell (MPMC) degranulation and histamine release in dose-dependent manner. Therefore, it is worth to study effect of curcumin on non-immunological stimulations as most often it occurs without IgE involvement. Whether it has mast cell membrane stabilizing activity or some other signaling mechanisms are involved underlying its potential could be explored further.},
 year = {2013}
}

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TY  - JOUR
T1  - Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis
AU  - Subhashini
AU  - Preeti Singh Chauhan
AU  - Sharda Kumari
AU  - Debabrata Dash
AU  - Rashmi Singh
Y1  - 2013/07/30
PY  - 2013
N1  - https://doi.org/10.11648/j.ajls.20130104.14
DO  - 10.11648/j.ajls.20130104.14
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 165
EP  - 170
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20130104.14
AB  - Curcumin, the active component of turmeric, is a polyphenolic phytochemical with anti-tumor, anti-inflammatory, anti-oxidative and anti-allergic properties. Mast cells participate in allergic inflammation by virtue of their ability of being activated to allergens and lead to the release of number of biologically active mediators including histamine, prostaglandins, leukotrienes, various cytokines etc. In this report, we have investigated effects of curcumin on non-immunological stimulations like Compound 48/80 induced systemic anaphylaxis. In vitro experiments have confirmed non-toxicity of curcumin (50µM) as assessed by MTT test but 100µM dose was found toxic. Curcumin (50µM) inhibited Compound 48/80 induced mouse peritoneal mast cell (MPMC) degranulation and histamine release in dose-dependent manner. Therefore, it is worth to study effect of curcumin on non-immunological stimulations as most often it occurs without IgE involvement. Whether it has mast cell membrane stabilizing activity or some other signaling mechanisms are involved underlying its potential could be explored further.
VL  - 1
IS  - 4
ER  -

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Author Information

Subhashini

Department of Zoology, MMV, Banaras Hindu University, Varanasi, India
Preeti Singh Chauhan

Department of Zoology, MMV, Banaras Hindu University, Varanasi, India
Sharda Kumari

Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India
Debabrata Dash

Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India
Rashmi Singh

Department of Zoology, MMV, Banaras Hindu University, Varanasi, India

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Plain Text BibTeX RIS

APA Style

Subhashini, Preeti Singh Chauhan, Sharda Kumari, Debabrata Dash, Rashmi Singh. (2013). Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis. American Journal of Life Sciences, 1(4), 165-170. https://doi.org/10.11648/j.ajls.20130104.14

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ACS Style

Subhashini; Preeti Singh Chauhan; Sharda Kumari; Debabrata Dash; Rashmi Singh. Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis. Am. J. Life Sci. 2013, 1(4), 165-170. doi: 10.11648/j.ajls.20130104.14

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AMA Style

Subhashini, Preeti Singh Chauhan, Sharda Kumari, Debabrata Dash, Rashmi Singh. Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis. Am J Life Sci. 2013;1(4):165-170. doi: 10.11648/j.ajls.20130104.14

Copy | Download

@article{10.11648/j.ajls.20130104.14,
  author = {Subhashini and Preeti Singh Chauhan and Sharda Kumari and Debabrata Dash and Rashmi Singh},
  title = {Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis},
  journal = {American Journal of Life Sciences},
  volume = {1},
  number = {4},
  pages = {165-170},
  doi = {10.11648/j.ajls.20130104.14},
  url = {https://doi.org/10.11648/j.ajls.20130104.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20130104.14},
  abstract = {Curcumin, the active component of turmeric, is a polyphenolic phytochemical with anti-tumor, anti-inflammatory, anti-oxidative and anti-allergic properties. Mast cells participate in allergic inflammation by virtue of their ability of being activated to allergens and lead to the release of number of biologically active mediators including histamine, prostaglandins, leukotrienes, various cytokines etc. In this report, we have investigated effects of curcumin on non-immunological stimulations like Compound 48/80 induced systemic anaphylaxis. In vitro experiments have confirmed non-toxicity of curcumin (50µM) as assessed by MTT test but 100µM dose was found toxic. Curcumin (50µM) inhibited Compound 48/80 induced mouse peritoneal mast cell (MPMC) degranulation and histamine release in dose-dependent manner. Therefore, it is worth to study effect of curcumin on non-immunological stimulations as most often it occurs without IgE involvement. Whether it has mast cell membrane stabilizing activity or some other signaling mechanisms are involved underlying its potential could be explored further.},
 year = {2013}
}

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TY  - JOUR
T1  - Curcumin Inhibits Compound 48/80 Induced Systemic Anaphylaxis
AU  - Subhashini
AU  - Preeti Singh Chauhan
AU  - Sharda Kumari
AU  - Debabrata Dash
AU  - Rashmi Singh
Y1  - 2013/07/30
PY  - 2013
N1  - https://doi.org/10.11648/j.ajls.20130104.14
DO  - 10.11648/j.ajls.20130104.14
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 165
EP  - 170
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20130104.14
AB  - Curcumin, the active component of turmeric, is a polyphenolic phytochemical with anti-tumor, anti-inflammatory, anti-oxidative and anti-allergic properties. Mast cells participate in allergic inflammation by virtue of their ability of being activated to allergens and lead to the release of number of biologically active mediators including histamine, prostaglandins, leukotrienes, various cytokines etc. In this report, we have investigated effects of curcumin on non-immunological stimulations like Compound 48/80 induced systemic anaphylaxis. In vitro experiments have confirmed non-toxicity of curcumin (50µM) as assessed by MTT test but 100µM dose was found toxic. Curcumin (50µM) inhibited Compound 48/80 induced mouse peritoneal mast cell (MPMC) degranulation and histamine release in dose-dependent manner. Therefore, it is worth to study effect of curcumin on non-immunological stimulations as most often it occurs without IgE involvement. Whether it has mast cell membrane stabilizing activity or some other signaling mechanisms are involved underlying its potential could be explored further.
VL  - 1
IS  - 4
ER  -

Copy | Download