Pharmacological Potentials of Melia Azedarach L. - A Review

Azam M. M.; Mamun-Or-Rashid A. N. M.; Towfique N. M.; Sen M. K.; Nasrin. S

doi:doi:10.11648/j.ajbio.20130102.13

| Peer-Reviewed

Pharmacological Potentials of Melia Azedarach L. - A Review

Azam M. M., Mamun-Or-Rashid A. N. M., Towfique N. M., Sen M. K., Nasrin. S

Published in American Journal of BioScience (Volume 1, Issue 2)

Received: 21 June 2013 Published: 10 July 2013

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Medicinal plants are widely used by the traditional medicinal practitioners to cure different diseases due to their world-wide availability and fewer side effects. Melia azedarach L. (Ghoda Neem locally) belongs to the family Meliaceae, is a highly significant medicinal plant found almost everywhere in Bangladesh. Traditionally, different parts such as leaf, flower, seed, fruit, and young branches of have been used for the treatment of malaria, diabetes, purgative, cough, skin disease, and so on. Experimental and clinical studies prove that it has antioxidant, antimicrobial, anti-inflammatory, cardioprotective, analgesic, anticancer, antiulcer, antipyretic, antiplasmodial and male contraceptive properties. For the last few decades or so, extensive research work has been done to prove its biological activities and pharmacology of its extracts. The present compendium review will focus on is traditional uses and pharmaceutical activities found on different scientific research and reports. This review also includes reports on phytochemistry, taxonomy, morphology, monographs, distribution and toxic effects of M. azedarach.

Published in	American Journal of BioScience (Volume 1, Issue 2)
DOI	10.11648/j.ajbio.20130102.13
Page(s)	44-49
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Melia Azedarach, Traditional Uses, Pharmaceutical Activities, Phytochemistry

References

[1]	Mahfuzul HMD, Bari ML, Inatsu Y, Vijay KJ and Kawamoto S. Antibacterial Activity of Guava (Psidium guajava L.) and Neem (Azadirachta idica A. Juss.) Extracts Against Foodborne Pathogens and Spoilage Bacteria. Foodborne pathogens disease. 2007; 4(4): 481-488.
[2]	Cordell GA. Bioderversity and drug discovery asymbiotic relationship. Phytochem. 2000; 55: 463-480.
[3]	Ramya S, Jepachanderamohan PJ, Alaguchamy N, Kalayanasundaram M and Jayakumararaj R. In Vitro Antibacterial Prospective of Crude Leaf Extracts of Melia azedarach Linn. against Selected Bacterial Strains. Ethnobot. Leaf. 2009; 13: 254-258.
[4]	Russell AB, Hardin JW and Grand L. Melia azedarach. In: Poisonous Plants of North Carolina. 1997: Retrieved 2008-JAN-26.
[5]	Biswas K, Chattopadhyay T, Banerjee RK and Bandyopadhyay U. Biological activities and medic-inal properties of neem (Azadirnchta indica). Curr. Sci. 2002; 82: 1336-1345.
[6]	Mugnai E. Azadirachta indica: Neem tree, the "village pharmacy". ASAT- Associazione Scienze Agrarie Tropicali . 2009.
[7]	Rastogi RP and Mehrotra BN. Compendium of Indian Medicinal Plants. Vol. I. CSIR Publication, India, 1. 1991: pp 833.
[8]	Rastogi RP and Mehrotra BN. Compendium of Indian Medicinal Plants. Vol. III. CSIR Publication, India, 1. 1993: pp 831.
[9]	Rastogi RP. Compendium of Indian Medicinal Plants. Vol. V. CSIR Publication, India, 1. 1998: pp 1060.
[10]	Khan AV, Parveen G, Alam MM and Singh VK. Ethnomedicinal uses of Neem in rural areas of Uttar Pradesh, India. Ethnomedicine and Pharmacognosy II, Recent Progress in Medicinal Plants volume 7, SciTech Publishing, 2002: pp. 319-326.
[11]	Ismail MYM, Assem NM and Zakriya M. Botanicals Promoting Oral and Dental Hygiene: A Review. Res. J. Pharm. Biol. Chem. Sci. 2010; 1: 202-206.
[12]	12. Eugene B, Deepak B, Martin J, Robert LM, Ramesh CS and David U. Neem, a tree for solving global problems. National Academy Press, Washington DC. 1992: ISBN: 0-309-04686-6.
[13]	Dai J, Yaylayan VA, Raghavan GSV and Paré JR. Extraction and colorimetric determination of azadirachtin-related limonoids in neem seed kernel. J. Agri. Food Chem. 1999; 47: 3738-3742.
[14]	Devi CU, Valencia N, Atul PK and Pillai CR. Anti-plasmodial effect of three medicinal plants: a preliminary study. Curr. Sci. 2001; 80: 917-919.
[15]	Subapirya R and Nagini S. Medicinal properties of Neem leaves: a review. Curr. Med. Chem. Anti Cancer Agents. 2005; 5: 149-156.
[16]	16. Alves PD, Brandão MGL, Nunan EA and Soares CDV. Chromatographic evaluation and antimicrobial activity of Neem (Azadirachta indica A. Juss., Meliaceae) leaves hydroalcoholic extracts. Revista Brasileira de Farmacognosia. 2009; 19: 510-515.
[17]	Dharani N, Rukunga G, Yenesew A, Mbora A, Mwaura L, Dawson I and Jamnadass R. Common Antimalarial Trees and Shrubs of East Africa: a Description of Species and a Guide to Cultivation and Conservation through Use. Dawson I (ed). The World Agroforestry Centre (ICRAF), Nairobi, Kenya. 2010.
[18]	Carpinella MC, Giorda LM, Ferrayoli CG and Palacios SM. Antifungal effects of different organic extracts from Melia azedarach L. on phytopathogenic fungi and their isolated active components. J. Agri. Food Chem. 2003; 51: 2506-2511.
[19]	Mossini SA, De Oliveira KP and Kemelmeier C. Inhibition of patulin production by Penicillium expansum cultured with neem (Azadirachta indica) leaf extracts. J. Basic Microbiol. 2004; 44: 106-113.
[20]	Mondali NK, Mojumdar A, Chatterje SK, Banerjee A, Datta JK and Gupta S. Antifungal activities and chemical characterization of Neem leaf extracts on the growth of some selected fungal species in vitro culture medium. J. App. Sci. Env. Management. 2009; 13(1): 49-53.
[21]	Dharani N and Yenesew A. Medicinal plants of East Africa: An illustrated guide. Publisher- Najma Dharani, in association with Drongo Editing & Publishing. 2010: ISBN 978-9966-05-167-8.
[22]	Sen A and Batra A. Evaluation of antimicrobial activity of different solvent extracts of medicinal plant: Melia azedarach L. Int. J. Curr. Pharm. Res. 2012; 4: 67-73.
[23]	Ahana N. The medicinal value of Azadirachta indica. Hindu Press, India. antimicrobial activity of Garlic and Onion extracts. Pharmazie 38(11), 747-748.(Internet search) Antimicrobial Activity. Part 1. Fitoterapia 51, 231. Antimicrobial Activity. Part 2. Fitoterapia. 2005; 51: 281.
[24]	Rai N, Grover A and Bhandari BS. Antimicrobial Activity of Medicinal plants- Azadirachta indica A. Juss, Allium cepa L. and Aloe vera L. Int. J. PharmTech Res. 2011; 3: 1059-1065.
[25]	Hirt HM and M’Pia B. Natural Medicines in the Tropics. Anamed, Action for natural medicine, Winnenden,Germany. 2001.
[26]	Neycee MA, Nematzadeh GHA, Dehestani A and Alavi M. Evaluation of antibacterial effects of chinaberry (Melia azedarach) against gram-positive and gram-negative bacteria. Int. J. Agri. Crop Sci. 2012; 4(11): 709-712.
[27]	Chakrabarty F, Kisku AK and Dolai MC. Health Maintaining and Disease Curative Ethno-medicinal and Religious Practices by the Santals of Keonjhar District, Orissa. IOSR J. Human. Social Sci. 2012; 2: 35-45.
[28]	Vijendra N and Kumar KP. Traditional knowledge on ethno-medicinal uses prevailing in tribal pockets of Chhindwara and Betul Districts, Madhya Pradesh, India. African J. Pharm. Pharmacol. 2010; 4: 662-670.
[29]	Lahitte HB, Hurrell JA, Valla JJ, Jankowski L, Bazzano D and Hernandez AJ. Biota ríoplatense IV, Arboles urbanos, LOLA, Buenos Aires. 1999: pp.192-195.
[30]	Kong YC, Ng KH, But PPH, LiQ, Yu SX, Zhang HT, Cheng KF, Soejarto DD, Kan WS and Waterman PG. Sources of the anti implantation alkaloid Yuehchukene in the genus murraya. J. Ethnopharmacol. 1986; 15: 195-200.
[31]	Vijayanandand S and Wesely EG. Phytochemical studies of Melia azadirachta & Murraya koeingi. Int. J. Pharm. Sci. Res. 2011; 2: 1298-1302.
[32]	Sharma PC, Yelne MB, Dennis TJ. Data base on medicinal plants used in Ayurveda. Central Council for Research in Ayurveda and Siddha, New Delhi. 2001: pp. 389-406.
[33]	Kumar VS, Sanghai DB, Rao MC and Shreedhara CS. Histological and physiochemical standardization of Melia azedarach Linn. bark. Asian Pacific J. Trop. Biomed. 2012: 284-289.
[34]	Akhtar M, Iqba Z, Khan MN and Lateef M. Anthelmintic activity of medicinal plants with particular reference to their use in animals in the Indo-Pakistan subcontinent. Small Ruminant Res. 2000; 38: 99-107.
[35]	McGraw LJ, Jäger AK and Staden VJ. Antibacterial, anthelmintic and antiamoebic activity in South African medicinal plants. J. Ethnopharmacol. 2000; 72: 247-263.
[36]	Szewczuk VD, Mongelli ER and Pomilio AB. Antiparasitic activity of Melia azedarach growing in Argentina. Mol. Med. Chem. 2003; 1: 54-57.
[37]	Jain A and Basal E. Inhibition of propionibacterium acnesinduced mediators of inflammation by Indian herbs. Phytomed. 2003; 10: 34-38.
[38]	Samudram P, Vasuki R, Rajeshwari H, Geetha A and Sathiya Moorthi P. Antioxidant and antihepatotoxic activities of ethanolic crude extract of Melia azedarach and Piper longum. J. Med. Plants Res. 2009; 3: 1078-1083.
[39]	Nahak G and Sahu RK. In vitro antioxidative acitivity of Azadirachta indica and Melia azedarach Leaves by DPPH scavenging assay. Nat. Sci. 2010; 8(4): 22-28.
[40]	Castilla V, Barquero AA, Mersich SE and Coto CE. Int. J. Antimicrobial Agents. 1998; 10: 67.
[41]	Abdel-Shafy S and Zayed AA. In vitro acaricidal effect of plant extract of neem seed oil (Azadirachta indica) on egg, immature, and adult stages of Hyalomma anatolicum excavatum (Ixodoidea : Ixodidae). Vet. Parasitol. 2002; 106: 89-96.
[42]	Sharma V, Walia S, Kumar J, Nair MG and Parmar BS. An efficient method for the purification and characterization of nematicidal azadirachtins A, B and H using MPLC and ESIMS. J. Agri. Food Chem. 2003; 51: 3966-3972.
[43]	Dixit VP, Sinha R and Tank R. Effect of neem seed oil on the blood glucose concentration of normal and alloxan diabetic rats. J. Ethnopharmacol. 1986; 17: 95-98.
[44]	Koul O, Isman MB and Ketkar CM. Properties and uses of neem, Azadirachta indica. Canadian J. Bot. 1990; 68: 1-11.
[45]	Chatterjee A and Pakrashi S. Treatise on Indian medicinal plants. New Delhi: Publications and Information Directorate. 1994: pp 80-82.
[46]	Silva JP, Crotti AEM and Cunha WR. Antifeedant and allelopathic activities of the hydroalcoholic extract obtained from Neem (Azadirachta indica) leaves. Brazilian J. Pharmacog. 2007; 17: 529-532.
[47]	Khanavi M, Hadjiakhoondi A, Sadeghipour Roodsari HR, Vosoughi M and Arbabi R. The effects of ethanolic extracts of Melia indica and Melia azedarach fruits on reproductive indices of male rats. J. Reprod. Infertility. 2007; 8: 7-16.

Cite This Article

Plain Text BibTeX RIS

APA Style

Azam M. M., Mamun-Or-Rashid A. N. M., Towfique N. M., Sen M. K., Nasrin. S. (2013). Pharmacological Potentials of Melia Azedarach L. - A Review. American Journal of BioScience, 1(2), 44-49. https://doi.org/10.11648/j.ajbio.20130102.13

Copy | Download

ACS Style

Azam M. M.; Mamun-Or-Rashid A. N. M.; Towfique N. M.; Sen M. K.; Nasrin. S. Pharmacological Potentials of Melia Azedarach L. - A Review. Am. J. BioScience 2013, 1(2), 44-49. doi: 10.11648/j.ajbio.20130102.13

Copy | Download

AMA Style

Azam M. M., Mamun-Or-Rashid A. N. M., Towfique N. M., Sen M. K., Nasrin. S. Pharmacological Potentials of Melia Azedarach L. - A Review. Am J BioScience. 2013;1(2):44-49. doi: 10.11648/j.ajbio.20130102.13

Copy | Download

@article{10.11648/j.ajbio.20130102.13,
  author = {Azam M. M. and Mamun-Or-Rashid A. N. M. and Towfique N. M. and Sen M. K. and Nasrin. S},
  title = {Pharmacological Potentials of Melia Azedarach L. - A Review},
  journal = {American Journal of BioScience},
  volume = {1},
  number = {2},
  pages = {44-49},
  doi = {10.11648/j.ajbio.20130102.13},
  url = {https://doi.org/10.11648/j.ajbio.20130102.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20130102.13},
  abstract = {Medicinal plants are widely used by the traditional medicinal practitioners to cure different diseases due to their world-wide availability and fewer side effects. Melia azedarach L. (Ghoda Neem locally) belongs to the family Meliaceae, is a highly significant medicinal plant found almost everywhere in Bangladesh. Traditionally, different parts such as leaf, flower, seed, fruit, and young branches of have been used for the treatment of malaria, diabetes, purgative, cough, skin disease, and so on. Experimental and clinical studies prove that it has antioxidant, antimicrobial, anti-inflammatory, cardioprotective, analgesic, anticancer, antiulcer, antipyretic, antiplasmodial and male contraceptive properties. For the last few decades or so, extensive research work has been done to prove its biological activities and pharmacology of its extracts. The present compendium review will focus on is traditional uses and pharmaceutical activities found on different scientific research and reports. This review also includes reports on phytochemistry, taxonomy, morphology, monographs, distribution and toxic effects of M. azedarach.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Pharmacological Potentials of Melia Azedarach L. - A Review
AU  - Azam M. M.
AU  - Mamun-Or-Rashid A. N. M.
AU  - Towfique N. M.
AU  - Sen M. K.
AU  - Nasrin. S
Y1  - 2013/07/10
PY  - 2013
N1  - https://doi.org/10.11648/j.ajbio.20130102.13
DO  - 10.11648/j.ajbio.20130102.13
T2  - American Journal of BioScience
JF  - American Journal of BioScience
JO  - American Journal of BioScience
SP  - 44
EP  - 49
PB  - Science Publishing Group
SN  - 2330-0167
UR  - https://doi.org/10.11648/j.ajbio.20130102.13
AB  - Medicinal plants are widely used by the traditional medicinal practitioners to cure different diseases due to their world-wide availability and fewer side effects. Melia azedarach L. (Ghoda Neem locally) belongs to the family Meliaceae, is a highly significant medicinal plant found almost everywhere in Bangladesh. Traditionally, different parts such as leaf, flower, seed, fruit, and young branches of have been used for the treatment of malaria, diabetes, purgative, cough, skin disease, and so on. Experimental and clinical studies prove that it has antioxidant, antimicrobial, anti-inflammatory, cardioprotective, analgesic, anticancer, antiulcer, antipyretic, antiplasmodial and male contraceptive properties. For the last few decades or so, extensive research work has been done to prove its biological activities and pharmacology of its extracts. The present compendium review will focus on is traditional uses and pharmaceutical activities found on different scientific research and reports. This review also includes reports on phytochemistry, taxonomy, morphology, monographs, distribution and toxic effects of M. azedarach.
VL  - 1
IS  - 2
ER  -

Copy | Download

Author Information

Azam M. M.

Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh
Mamun-Or-Rashid A. N. M.

Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh
Towfique N. M.

Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh
Sen M. K.

Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh
Nasrin. S

Scientific Officer, Plant Biotechnology Division, National Institute of Biotechnology, Savar, Dhaka, Bangladesh

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Azam M. M., Mamun-Or-Rashid A. N. M., Towfique N. M., Sen M. K., Nasrin. S. (2013). Pharmacological Potentials of Melia Azedarach L. - A Review. American Journal of BioScience, 1(2), 44-49. https://doi.org/10.11648/j.ajbio.20130102.13

Copy | Download

ACS Style

Azam M. M.; Mamun-Or-Rashid A. N. M.; Towfique N. M.; Sen M. K.; Nasrin. S. Pharmacological Potentials of Melia Azedarach L. - A Review. Am. J. BioScience 2013, 1(2), 44-49. doi: 10.11648/j.ajbio.20130102.13

Copy | Download

AMA Style

Azam M. M., Mamun-Or-Rashid A. N. M., Towfique N. M., Sen M. K., Nasrin. S. Pharmacological Potentials of Melia Azedarach L. - A Review. Am J BioScience. 2013;1(2):44-49. doi: 10.11648/j.ajbio.20130102.13

Copy | Download

@article{10.11648/j.ajbio.20130102.13,
  author = {Azam M. M. and Mamun-Or-Rashid A. N. M. and Towfique N. M. and Sen M. K. and Nasrin. S},
  title = {Pharmacological Potentials of Melia Azedarach L. - A Review},
  journal = {American Journal of BioScience},
  volume = {1},
  number = {2},
  pages = {44-49},
  doi = {10.11648/j.ajbio.20130102.13},
  url = {https://doi.org/10.11648/j.ajbio.20130102.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20130102.13},
  abstract = {Medicinal plants are widely used by the traditional medicinal practitioners to cure different diseases due to their world-wide availability and fewer side effects. Melia azedarach L. (Ghoda Neem locally) belongs to the family Meliaceae, is a highly significant medicinal plant found almost everywhere in Bangladesh. Traditionally, different parts such as leaf, flower, seed, fruit, and young branches of have been used for the treatment of malaria, diabetes, purgative, cough, skin disease, and so on. Experimental and clinical studies prove that it has antioxidant, antimicrobial, anti-inflammatory, cardioprotective, analgesic, anticancer, antiulcer, antipyretic, antiplasmodial and male contraceptive properties. For the last few decades or so, extensive research work has been done to prove its biological activities and pharmacology of its extracts. The present compendium review will focus on is traditional uses and pharmaceutical activities found on different scientific research and reports. This review also includes reports on phytochemistry, taxonomy, morphology, monographs, distribution and toxic effects of M. azedarach.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Pharmacological Potentials of Melia Azedarach L. - A Review
AU  - Azam M. M.
AU  - Mamun-Or-Rashid A. N. M.
AU  - Towfique N. M.
AU  - Sen M. K.
AU  - Nasrin. S
Y1  - 2013/07/10
PY  - 2013
N1  - https://doi.org/10.11648/j.ajbio.20130102.13
DO  - 10.11648/j.ajbio.20130102.13
T2  - American Journal of BioScience
JF  - American Journal of BioScience
JO  - American Journal of BioScience
SP  - 44
EP  - 49
PB  - Science Publishing Group
SN  - 2330-0167
UR  - https://doi.org/10.11648/j.ajbio.20130102.13
AB  - Medicinal plants are widely used by the traditional medicinal practitioners to cure different diseases due to their world-wide availability and fewer side effects. Melia azedarach L. (Ghoda Neem locally) belongs to the family Meliaceae, is a highly significant medicinal plant found almost everywhere in Bangladesh. Traditionally, different parts such as leaf, flower, seed, fruit, and young branches of have been used for the treatment of malaria, diabetes, purgative, cough, skin disease, and so on. Experimental and clinical studies prove that it has antioxidant, antimicrobial, anti-inflammatory, cardioprotective, analgesic, anticancer, antiulcer, antipyretic, antiplasmodial and male contraceptive properties. For the last few decades or so, extensive research work has been done to prove its biological activities and pharmacology of its extracts. The present compendium review will focus on is traditional uses and pharmaceutical activities found on different scientific research and reports. This review also includes reports on phytochemistry, taxonomy, morphology, monographs, distribution and toxic effects of M. azedarach.
VL  - 1
IS  - 2
ER  -

Copy | Download