Effect of Test- and -Treat Strategy on Antiretroviral Drugs Uptake in a Prevention of Mother to Child Transmission Programme in Southwest Nigeria

Abayomi Joseph Afe; Isah Haroun; Kemi Edet-Utan; Timothy Akinmurele

doi:doi:10.11648/j.sjph.20140205.25

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Effect of Test- and -Treat Strategy on Antiretroviral Drugs Uptake in a Prevention of Mother to Child Transmission Programme in Southwest Nigeria

Abayomi Joseph Afe, Isah Haroun, Kemi Edet-Utan, Timothy Akinmurele

Published in Science Journal of Public Health (Volume 2, Issue 5)

Received: 30 August 2014 Accepted: 17 September 2014 Published: 30 September 2014

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Abstract

A multicenter retrospective case-control study. Study subjects were HIV positive pregnant women enrolled in a prevention of mother to child transmission of HIV(PMTCT) programme in southwest Nigeria. The objective was to see if the introduction of ‘Test- and -Treat strategy’ would lead to placing higher number of HIV-POSITIVE pregnant women on antiretroviral drugs. There was a significant difference (OR=1.4;CI=1.35-1.55,P=0.0) in the proportions of HIV-POSITIVE pregnant women initiated on ARV between the control arm(60%) and the case group(81%)with the implementation of the strategy. In other words, an HIV POSITIVE woman in a PMTCT setting has a 40% greater chance of being placed on ARV with test-and-treat strategy than without the strategy.The test- and -treat strategy is a treatment approach in which HIV positive clients are initiated on prophylactic antiretroviral drugs immediately after HIV diagnosis without waiting for the CD4 count test result. Hence, implementing Test and Treat Strategy in a PMTCT programme increases the antiretroviral drug uptake by HIV-POSITIVE women which in turn could lead to a reduced rate of vertical transmission of HIV, as a result of the suppressed maternal viral load.

Published in	Science Journal of Public Health (Volume 2, Issue 5)
DOI	10.11648/j.sjph.20140205.25
Page(s)	476-479
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

PMTCT (Prevention of Mother To Child Transmission of HIV), IHVN (Institute of Human Virology Nigeria), CD4-T-lymphocytes (CD4 Cells), ART (Antiretroviral Therapy), PLHIV (People Living with HIV), Antiretroviral Drugs (ARV)

References

[1]	UNAIDS 2013 Report on the global AIDS epidemic (http://www.unaids.org/en/resources/presscentre/pressreleaseandstatementarchive/2013/september/20130923prunga/[9/26/2013]
[2]	WHO, UNAIDS and UNICEF. Progress report 2011: global HIV/AIDS response. Epidemic uptake and health sector progress towards universal access. Geneva, World Health Organization, 2011 (www.who.int/hiv/pub/progress_report2011/en/index.html, accessed 15 May 20.
[3]	Cohen MS, Chen YQ, McCauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365:493-505.
[4]	Joint United Nations Programme on HIV/AIDS, 2013 Progress on the Global Plan towards the Elimination of New HIV Infections among Children by 2015 and Keeping their Mothers Alive, UNAIDS, Geneva, 2013.
[5]	World Health Organization, The Joint United Nations Programme on HIV/AIDS, the United Nations Children’s Fund. Towards universal access: scaling up priority HIV/AIDS interventions in the health sector: progress report 2008. Geneva: WHO;2008.
[6]	Nigerian National Agency for the Control of AIDS: Global AIDS Response Progress report (GARPR), 2012 pg. 30
[7]	Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Recommendations for a public health approach, World Health Organization, June 2013
[8]	Nigerian National PMTCT Guidelines 2010, Laboratory Diagnosis of HIV Infection in Pregnant Women, pg 10-18
[9]	2010 National HIV Sero-prevalence Sentinel Survey .page 44
[10]	David B. H, Nancy A. H, Elizabeth T. G. et al. Increase in Single-Tablet Regimen Use and Associated Improvements in Adherence-Related Outcomes in HIV-Infected Women J Acquir Immune Defic Syndr. 2014;65: 587-596.
[11]	Carla J. C, Mark J. G, Nande P, et al. Optimal Time on HAART for Prevention of Mother-to-child Transmission of HIV . J Acquir Immune Defic Syndr. 2011;58: 224-228
[12]	Federal Ministry of Health, National Scale Up Plan Towards Elimination Of Mother To Child Transmission Of HIV In Nigeria 2010 – 2015 pg.2-17.

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APA Style

Abayomi Joseph Afe, Isah Haroun, Kemi Edet-Utan, Timothy Akinmurele. (2014). Effect of Test- and -Treat Strategy on Antiretroviral Drugs Uptake in a Prevention of Mother to Child Transmission Programme in Southwest Nigeria. Science Journal of Public Health, 2(5), 476-479. https://doi.org/10.11648/j.sjph.20140205.25

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ACS Style

Abayomi Joseph Afe; Isah Haroun; Kemi Edet-Utan; Timothy Akinmurele. Effect of Test- and -Treat Strategy on Antiretroviral Drugs Uptake in a Prevention of Mother to Child Transmission Programme in Southwest Nigeria. Sci. J. Public Health 2014, 2(5), 476-479. doi: 10.11648/j.sjph.20140205.25

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AMA Style

Abayomi Joseph Afe, Isah Haroun, Kemi Edet-Utan, Timothy Akinmurele. Effect of Test- and -Treat Strategy on Antiretroviral Drugs Uptake in a Prevention of Mother to Child Transmission Programme in Southwest Nigeria. Sci J Public Health. 2014;2(5):476-479. doi: 10.11648/j.sjph.20140205.25

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@article{10.11648/j.sjph.20140205.25,
  author = {Abayomi Joseph Afe and Isah Haroun and Kemi Edet-Utan and Timothy Akinmurele},
  title = {Effect of Test- and -Treat Strategy on Antiretroviral Drugs Uptake in a Prevention of Mother to Child Transmission Programme in Southwest Nigeria},
  journal = {Science Journal of Public Health},
  volume = {2},
  number = {5},
  pages = {476-479},
  doi = {10.11648/j.sjph.20140205.25},
  url = {https://doi.org/10.11648/j.sjph.20140205.25},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20140205.25},
  abstract = {A multicenter retrospective case-control study. Study subjects were HIV positive pregnant women enrolled in a prevention of mother to child transmission of HIV(PMTCT) programme in southwest Nigeria. The objective was to see if the introduction of ‘Test- and -Treat strategy’ would lead to placing higher number of HIV-POSITIVE pregnant women on antiretroviral drugs. There was a significant difference (OR=1.4;CI=1.35-1.55,P=0.0) in the proportions of HIV-POSITIVE pregnant women initiated on ARV between the control arm(60%) and the case group(81%)with the implementation of the strategy. In other words, an HIV POSITIVE woman in  a PMTCT setting has a 40% greater chance of being placed on ARV with test-and-treat strategy than without the strategy.The  test- and -treat strategy is a treatment approach in which HIV positive clients are initiated on prophylactic antiretroviral drugs immediately after HIV diagnosis without waiting for the CD4 count test result. Hence, implementing Test and Treat Strategy in a PMTCT programme increases the antiretroviral drug uptake by HIV-POSITIVE women which in turn could lead to a reduced rate of vertical transmission of HIV, as a result of the suppressed maternal viral load.},
 year = {2014}
}

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TY  - JOUR
T1  - Effect of Test- and -Treat Strategy on Antiretroviral Drugs Uptake in a Prevention of Mother to Child Transmission Programme in Southwest Nigeria
AU  - Abayomi Joseph Afe
AU  - Isah Haroun
AU  - Kemi Edet-Utan
AU  - Timothy Akinmurele
Y1  - 2014/09/30
PY  - 2014
N1  - https://doi.org/10.11648/j.sjph.20140205.25
DO  - 10.11648/j.sjph.20140205.25
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 476
EP  - 479
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20140205.25
AB  - A multicenter retrospective case-control study. Study subjects were HIV positive pregnant women enrolled in a prevention of mother to child transmission of HIV(PMTCT) programme in southwest Nigeria. The objective was to see if the introduction of ‘Test- and -Treat strategy’ would lead to placing higher number of HIV-POSITIVE pregnant women on antiretroviral drugs. There was a significant difference (OR=1.4;CI=1.35-1.55,P=0.0) in the proportions of HIV-POSITIVE pregnant women initiated on ARV between the control arm(60%) and the case group(81%)with the implementation of the strategy. In other words, an HIV POSITIVE woman in  a PMTCT setting has a 40% greater chance of being placed on ARV with test-and-treat strategy than without the strategy.The  test- and -treat strategy is a treatment approach in which HIV positive clients are initiated on prophylactic antiretroviral drugs immediately after HIV diagnosis without waiting for the CD4 count test result. Hence, implementing Test and Treat Strategy in a PMTCT programme increases the antiretroviral drug uptake by HIV-POSITIVE women which in turn could lead to a reduced rate of vertical transmission of HIV, as a result of the suppressed maternal viral load.
VL  - 2
IS  - 5
ER  -

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Author Information

Abayomi Joseph Afe

Community Medicine Department, Equitable Health Access Initiative, Lagos Nigeria
Isah Haroun

Community Health Department, Institute of Human Virology Nigeria, Abuja, Nigeria
Kemi Edet-Utan

Community Medicine Department, Equitable Health Access Initiative, Lagos Nigeria
Timothy Akinmurele

Community Medicine Department, Equitable Health Access Initiative, Lagos Nigeria

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APA Style

Abayomi Joseph Afe, Isah Haroun, Kemi Edet-Utan, Timothy Akinmurele. (2014). Effect of Test- and -Treat Strategy on Antiretroviral Drugs Uptake in a Prevention of Mother to Child Transmission Programme in Southwest Nigeria. Science Journal of Public Health, 2(5), 476-479. https://doi.org/10.11648/j.sjph.20140205.25

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ACS Style

Abayomi Joseph Afe; Isah Haroun; Kemi Edet-Utan; Timothy Akinmurele. Effect of Test- and -Treat Strategy on Antiretroviral Drugs Uptake in a Prevention of Mother to Child Transmission Programme in Southwest Nigeria. Sci. J. Public Health 2014, 2(5), 476-479. doi: 10.11648/j.sjph.20140205.25

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AMA Style

Abayomi Joseph Afe, Isah Haroun, Kemi Edet-Utan, Timothy Akinmurele. Effect of Test- and -Treat Strategy on Antiretroviral Drugs Uptake in a Prevention of Mother to Child Transmission Programme in Southwest Nigeria. Sci J Public Health. 2014;2(5):476-479. doi: 10.11648/j.sjph.20140205.25

Copy | Download

@article{10.11648/j.sjph.20140205.25,
  author = {Abayomi Joseph Afe and Isah Haroun and Kemi Edet-Utan and Timothy Akinmurele},
  title = {Effect of Test- and -Treat Strategy on Antiretroviral Drugs Uptake in a Prevention of Mother to Child Transmission Programme in Southwest Nigeria},
  journal = {Science Journal of Public Health},
  volume = {2},
  number = {5},
  pages = {476-479},
  doi = {10.11648/j.sjph.20140205.25},
  url = {https://doi.org/10.11648/j.sjph.20140205.25},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20140205.25},
  abstract = {A multicenter retrospective case-control study. Study subjects were HIV positive pregnant women enrolled in a prevention of mother to child transmission of HIV(PMTCT) programme in southwest Nigeria. The objective was to see if the introduction of ‘Test- and -Treat strategy’ would lead to placing higher number of HIV-POSITIVE pregnant women on antiretroviral drugs. There was a significant difference (OR=1.4;CI=1.35-1.55,P=0.0) in the proportions of HIV-POSITIVE pregnant women initiated on ARV between the control arm(60%) and the case group(81%)with the implementation of the strategy. In other words, an HIV POSITIVE woman in  a PMTCT setting has a 40% greater chance of being placed on ARV with test-and-treat strategy than without the strategy.The  test- and -treat strategy is a treatment approach in which HIV positive clients are initiated on prophylactic antiretroviral drugs immediately after HIV diagnosis without waiting for the CD4 count test result. Hence, implementing Test and Treat Strategy in a PMTCT programme increases the antiretroviral drug uptake by HIV-POSITIVE women which in turn could lead to a reduced rate of vertical transmission of HIV, as a result of the suppressed maternal viral load.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Effect of Test- and -Treat Strategy on Antiretroviral Drugs Uptake in a Prevention of Mother to Child Transmission Programme in Southwest Nigeria
AU  - Abayomi Joseph Afe
AU  - Isah Haroun
AU  - Kemi Edet-Utan
AU  - Timothy Akinmurele
Y1  - 2014/09/30
PY  - 2014
N1  - https://doi.org/10.11648/j.sjph.20140205.25
DO  - 10.11648/j.sjph.20140205.25
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 476
EP  - 479
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20140205.25
AB  - A multicenter retrospective case-control study. Study subjects were HIV positive pregnant women enrolled in a prevention of mother to child transmission of HIV(PMTCT) programme in southwest Nigeria. The objective was to see if the introduction of ‘Test- and -Treat strategy’ would lead to placing higher number of HIV-POSITIVE pregnant women on antiretroviral drugs. There was a significant difference (OR=1.4;CI=1.35-1.55,P=0.0) in the proportions of HIV-POSITIVE pregnant women initiated on ARV between the control arm(60%) and the case group(81%)with the implementation of the strategy. In other words, an HIV POSITIVE woman in  a PMTCT setting has a 40% greater chance of being placed on ARV with test-and-treat strategy than without the strategy.The  test- and -treat strategy is a treatment approach in which HIV positive clients are initiated on prophylactic antiretroviral drugs immediately after HIV diagnosis without waiting for the CD4 count test result. Hence, implementing Test and Treat Strategy in a PMTCT programme increases the antiretroviral drug uptake by HIV-POSITIVE women which in turn could lead to a reduced rate of vertical transmission of HIV, as a result of the suppressed maternal viral load.
VL  - 2
IS  - 5
ER  -

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