The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study

Huifeng Jin; Rolando Lorenzo Maddela; Robert Andrew Sinnott

doi:doi:10.11648/j.jfns.20200805.12

| Peer-Reviewed

The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study

Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott

Published in Journal of Food and Nutrition Sciences (Volume 8, Issue 5)

Received: 7 October 2020 Accepted: 22 October 2020 Published: 30 October 2020

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Abstract

Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.

Published in	Journal of Food and Nutrition Sciences (Volume 8, Issue 5)
DOI	10.11648/j.jfns.20200805.12
Page(s)	127-138
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Cardio-Metabolic Risk Biomarkers, Oxidative Stress, Inflammation, MVMMs, Antioxidant Nutrients, NHANES, Multiple Regression

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Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott. (2020). The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. Journal of Food and Nutrition Sciences, 8(5), 127-138. https://doi.org/10.11648/j.jfns.20200805.12

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Huifeng Jin; Rolando Lorenzo Maddela; Robert Andrew Sinnott. The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. J. Food Nutr. Sci. 2020, 8(5), 127-138. doi: 10.11648/j.jfns.20200805.12

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Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott. The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. J Food Nutr Sci. 2020;8(5):127-138. doi: 10.11648/j.jfns.20200805.12

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@article{10.11648/j.jfns.20200805.12,
  author = {Huifeng Jin and Rolando Lorenzo Maddela and Robert Andrew Sinnott},
  title = {The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {8},
  number = {5},
  pages = {127-138},
  doi = {10.11648/j.jfns.20200805.12},
  url = {https://doi.org/10.11648/j.jfns.20200805.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20200805.12},
  abstract = {Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.},
 year = {2020}
}

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TY  - JOUR
T1  - The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study
AU  - Huifeng Jin
AU  - Rolando Lorenzo Maddela
AU  - Robert Andrew Sinnott
Y1  - 2020/10/30
PY  - 2020
N1  - https://doi.org/10.11648/j.jfns.20200805.12
DO  - 10.11648/j.jfns.20200805.12
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 127
EP  - 138
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20200805.12
AB  - Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.
VL  - 8
IS  - 5
ER  -

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Author Information

Huifeng Jin

Research and Development, USANA Health Sciences, Inc., Salt Lake City, USA
Rolando Lorenzo Maddela

Research and Development, USANA Health Sciences, Inc., Salt Lake City, USA
Robert Andrew Sinnott

Research and Development, USANA Health Sciences, Inc., Salt Lake City, USA

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Plain Text BibTeX RIS

APA Style

Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott. (2020). The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. Journal of Food and Nutrition Sciences, 8(5), 127-138. https://doi.org/10.11648/j.jfns.20200805.12

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ACS Style

Huifeng Jin; Rolando Lorenzo Maddela; Robert Andrew Sinnott. The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. J. Food Nutr. Sci. 2020, 8(5), 127-138. doi: 10.11648/j.jfns.20200805.12

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AMA Style

Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott. The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. J Food Nutr Sci. 2020;8(5):127-138. doi: 10.11648/j.jfns.20200805.12

Copy | Download

@article{10.11648/j.jfns.20200805.12,
  author = {Huifeng Jin and Rolando Lorenzo Maddela and Robert Andrew Sinnott},
  title = {The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {8},
  number = {5},
  pages = {127-138},
  doi = {10.11648/j.jfns.20200805.12},
  url = {https://doi.org/10.11648/j.jfns.20200805.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20200805.12},
  abstract = {Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study
AU  - Huifeng Jin
AU  - Rolando Lorenzo Maddela
AU  - Robert Andrew Sinnott
Y1  - 2020/10/30
PY  - 2020
N1  - https://doi.org/10.11648/j.jfns.20200805.12
DO  - 10.11648/j.jfns.20200805.12
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 127
EP  - 138
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20200805.12
AB  - Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.
VL  - 8
IS  - 5
ER  -

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