Association Between Glycaemic Control and Serum Lipid Profile of Type 2 Diabetic Patients in University College Hospital Ibadan, Oyo State, Nigeria

Funmilayo Esther Omotoye; Grace Tanimoowo Fadupin

doi:doi:10.11648/j.jfns.20160404.14

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Association Between Glycaemic Control and Serum Lipid Profile of Type 2 Diabetic Patients in University College Hospital Ibadan, Oyo State, Nigeria

Funmilayo Esther Omotoye, Grace Tanimoowo Fadupin

Published in Journal of Food and Nutrition Sciences (Volume 4, Issue 4)

Received: 14 June 2016 Accepted: 24 June 2016 Published: 6 July 2016

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Abstract

Diabetes mellitus is a chronic disease that requires long term medical attention both to limit the development of its devastating complications and manage them when they occur. Lowering high blood sugar in patients with diabetes (glycaemic control) is essential to reduce their risk of complications associated with diabetes. This study was designed to assess the effect of glycaemic control on the serum lipid profile of type II diabetic patients in the university college hospital Ibadan, Oyo State. The study was descriptive cross sectional in design to assess the effect of glycaemic control on serum lipid profile of the participants. A total of 50 consenting adults, aged 40-72 years, 20 (40%) males and 30 (60%) females, type II diabetic patients were studied between March and August 2006. The demographic characteristics and dietary pattern of the participants were assessed through a semi-structured interviewer administered questionnaire and food frequency questionnaire. The serum lipids of participants for the last six months and the mean of their last four fasting blood glucose (FBG) levels were assessed from their hospital records. The effect of the glycaemic index on their lipid profile was determined using correlation coefficient and chi-square. The mean age of the respondents was 57.82±3.3 years. They were predominantly 45 (90%) Yorubas. A total of 68% had either secondary or post secondary/tertiary education. Their main source of energy was from cereals, grains and tuber crops while legumes were their major source of protein. A total of 33 (66%) had controlled (normal) fasting blood glucose while 17 (34%) did not have their FBG controlled. Only 17 (34%) had normal high density lipoprotein (HDL) cholesterol while 35 (70%) and 33 (66%) had normal low density lipoprotein (LDL) cholesterol and total cholesterol respectively. The FBG of participants had an inverse relationship with HDL but positive relationship with LDL, total cholesterol and triglyceride levels of the participants. However, the effect of FBG was only significant on triglyceride level of respondents (P=0.033) and not significant on HDL, LDL, and total cholesterol (P>0.05). Good glycemic control significantly improves dyslipidemia in type 2 diabetic patients.

Published in	Journal of Food and Nutrition Sciences (Volume 4, Issue 4)
DOI	10.11648/j.jfns.20160404.14
Page(s)	98-102
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Type II Diabetes, Serum Lipids Profile, Glycaemic Control, Fasting Blood Glucose

References

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[2]	R. VinodMahato, P. Gyawali, P. P. Raut et al. Association between glycaemic control and serum lipid profile in type 2 diabetic patients: Glycated haemoglobin as a dual biomarker. Biomed Res 2011; 22 (3): 375-380.
[3]	H. A. Khan, S. H. Sobki, S. A. Khan. Association between glycemic control and serum lipid profile in type II diabetic patients: HbA1c predicts dyslipidaemia. Clin Exp Med. 2007: 7 (1): 24-29.
[4]	SM Manohar, SR Vaikasuvu, K Deepthi, A Sachan, SRPVL Narasimha. An association of hyperglycemia with plasma malondialdehyde and atherogenic lipid risk factors in newly diagnosed Type 2 diabetic patients. J Res Med Sci 2013; 18: 89-93.
[5]	B. Redmon, D. Caccamo, P. Flavin, R. Michels, P. O’Connor, J. Roberts, S. Smith, J. Sperl-Hillen. Diagnosis and Management of Type 2 Diabetes Mellitus in Adults. Institute for Clinical Systems Improvement. 2014; 16: 1-33.
[6]	World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: Report of a WHO/IDF Consultation. II. International Diabetes Federation WHO Press, 20 Avenue Appia, 1211 Geneva 27, 2006 bookorders@ who.int. pp 1
[7]	Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). National Institutes of Health. 2001; 01-3670, 3-18 pp.
[8]	American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care 2010; 33; suppl 1: S 62-69.
[9]	E. H. Hilawe, H. Yatsuyah, L. Kawaguchi et al. Differences by sex in the prevalence of diabetes mellitus, impaired fasting glycaemia and impaired glucose tolerance in sub-Saharan African: a systematic review and met-analysis. Bulletin of WHO 2013; 91 (9): 621-715.
[10]	D. K. Tobias, A. Pan, C. L. Jackson, et al. Body-Mass Index and Mortality among Adults with Incident Type 2 Diabetes. N Engl J Med 2014; 370: 233-244.
[11]	American Diabetes Association. Classification and Diagnosis of Diabetes. Diabetes Care 2016; 39 (Suppl 1): S 13-S 22.
[12]	Sattar N. Gender aspects in type 2 diabetes mellitus and cardio-metabolic risk. Best Pract Res Clin Endocrinol Metab. 2013; 27 (4): 501–507.
[13]	L. Arnetz, N. R. Ekberg, M. Alvarsson. Sex differences in type 2 diabetes: focus on disease course and outcomes. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2014; 7: 409–420.
[14]	Peters SA¹, Huxley RR, Woodward M. Diabetes as risk factor for incident coronary heart disease in women compared with men: a systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events. Diabetologia. 2014; 57 (8): 1542-51.
[15]	Iciar Martín-Timón, Cristina Sevillano-Collantes, Amparo Segura-Galindo, Francisco Javier del Cañizo-Gómez. Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength? World J Diabetes 2014; 15; 5 (4): 444-470.
[16]	Tangvarasittichai. Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World J Diabetes. 2015; 15; 6 (3): 456-480.
[17]	W. Liya, K. G. Parhofer. Diabetic dyslipidemia. Metabol. 2014; 63: (12): 1469–1479.

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APA Style

Funmilayo Esther Omotoye, Grace Tanimoowo Fadupin. (2016). Association Between Glycaemic Control and Serum Lipid Profile of Type 2 Diabetic Patients in University College Hospital Ibadan, Oyo State, Nigeria. Journal of Food and Nutrition Sciences, 4(4), 98-102. https://doi.org/10.11648/j.jfns.20160404.14

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ACS Style

Funmilayo Esther Omotoye; Grace Tanimoowo Fadupin. Association Between Glycaemic Control and Serum Lipid Profile of Type 2 Diabetic Patients in University College Hospital Ibadan, Oyo State, Nigeria. J. Food Nutr. Sci. 2016, 4(4), 98-102. doi: 10.11648/j.jfns.20160404.14

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AMA Style

Funmilayo Esther Omotoye, Grace Tanimoowo Fadupin. Association Between Glycaemic Control and Serum Lipid Profile of Type 2 Diabetic Patients in University College Hospital Ibadan, Oyo State, Nigeria. J Food Nutr Sci. 2016;4(4):98-102. doi: 10.11648/j.jfns.20160404.14

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@article{10.11648/j.jfns.20160404.14,
  author = {Funmilayo Esther Omotoye and Grace Tanimoowo Fadupin},
  title = {Association Between Glycaemic Control and Serum Lipid Profile of Type 2 Diabetic Patients in University College Hospital Ibadan, Oyo State, Nigeria},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {4},
  number = {4},
  pages = {98-102},
  doi = {10.11648/j.jfns.20160404.14},
  url = {https://doi.org/10.11648/j.jfns.20160404.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20160404.14},
  abstract = {Diabetes mellitus is a chronic disease that requires long term medical attention both to limit the development of its devastating complications and manage them when they occur. Lowering high blood sugar in patients with diabetes (glycaemic control) is essential to reduce their risk of complications associated with diabetes. This study was designed to assess the effect of glycaemic control on the serum lipid profile of type II diabetic patients in the university college hospital Ibadan, Oyo State. The study was descriptive cross sectional in design to assess the effect of glycaemic control on serum lipid profile of the participants. A total of 50 consenting adults, aged 40-72 years, 20 (40%) males and 30 (60%) females, type II diabetic patients were studied between March and August 2006. The demographic characteristics and dietary pattern of the participants were assessed through a semi-structured interviewer administered questionnaire and food frequency questionnaire. The serum lipids of participants for the last six months and the mean of their last four fasting blood glucose (FBG) levels were assessed from their hospital records. The effect of the glycaemic index on their lipid profile was determined using correlation coefficient and chi-square. The mean age of the respondents was 57.82±3.3 years. They were predominantly 45 (90%) Yorubas. A total of 68% had either secondary or post secondary/tertiary education. Their main source of energy was from cereals, grains and tuber crops while legumes were their major source of protein. A total of 33 (66%) had controlled (normal) fasting blood glucose while 17 (34%) did not have their FBG controlled. Only 17 (34%) had normal high density lipoprotein (HDL) cholesterol while 35 (70%) and 33 (66%) had normal low density lipoprotein (LDL) cholesterol and total cholesterol respectively. The FBG of participants had an inverse relationship with HDL but positive relationship with LDL, total cholesterol and triglyceride levels of the participants. However, the effect of FBG was only significant on triglyceride level of respondents (P=0.033) and not significant on HDL, LDL, and total cholesterol (P>0.05). Good glycemic control significantly improves dyslipidemia in type 2 diabetic patients.},
 year = {2016}
}

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TY - JOUR
T1 - Association Between Glycaemic Control and Serum Lipid Profile of Type 2 Diabetic Patients in University College Hospital Ibadan, Oyo State, Nigeria
AU - Funmilayo Esther Omotoye
AU - Grace Tanimoowo Fadupin
Y1 - 2016/07/06
PY - 2016
N1 - https://doi.org/10.11648/j.jfns.20160404.14
DO - 10.11648/j.jfns.20160404.14
T2 - Journal of Food and Nutrition Sciences
JF - Journal of Food and Nutrition Sciences
JO - Journal of Food and Nutrition Sciences
SP - 98
EP - 102
PB - Science Publishing Group
SN - 2330-7293
UR - https://doi.org/10.11648/j.jfns.20160404.14
AB - Diabetes mellitus is a chronic disease that requires long term medical attention both to limit the development of its devastating complications and manage them when they occur. Lowering high blood sugar in patients with diabetes (glycaemic control) is essential to reduce their risk of complications associated with diabetes. This study was designed to assess the effect of glycaemic control on the serum lipid profile of type II diabetic patients in the university college hospital Ibadan, Oyo State. The study was descriptive cross sectional in design to assess the effect of glycaemic control on serum lipid profile of the participants. A total of 50 consenting adults, aged 40-72 years, 20 (40%) males and 30 (60%) females, type II diabetic patients were studied between March and August 2006. The demographic characteristics and dietary pattern of the participants were assessed through a semi-structured interviewer administered questionnaire and food frequency questionnaire. The serum lipids of participants for the last six months and the mean of their last four fasting blood glucose (FBG) levels were assessed from their hospital records. The effect of the glycaemic index on their lipid profile was determined using correlation coefficient and chi-square. The mean age of the respondents was 57.82±3.3 years. They were predominantly 45 (90%) Yorubas. A total of 68% had either secondary or post secondary/tertiary education. Their main source of energy was from cereals, grains and tuber crops while legumes were their major source of protein. A total of 33 (66%) had controlled (normal) fasting blood glucose while 17 (34%) did not have their FBG controlled. Only 17 (34%) had normal high density lipoprotein (HDL) cholesterol while 35 (70%) and 33 (66%) had normal low density lipoprotein (LDL) cholesterol and total cholesterol respectively. The FBG of participants had an inverse relationship with HDL but positive relationship with LDL, total cholesterol and triglyceride levels of the participants. However, the effect of FBG was only significant on triglyceride level of respondents (P=0.033) and not significant on HDL, LDL, and total cholesterol (P>0.05). Good glycemic control significantly improves dyslipidemia in type 2 diabetic patients.
VL - 4
IS - 4
ER -

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Author Information

Funmilayo Esther Omotoye

Department of Human Nutrition, Faculty of Public Health, University of Ibadan, Ibadan, Oyo State, Nigeria
Grace Tanimoowo Fadupin

Department of Human Nutrition, Faculty of Public Health, University of Ibadan, Ibadan, Oyo State, Nigeria

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APA Style

Funmilayo Esther Omotoye, Grace Tanimoowo Fadupin. (2016). Association Between Glycaemic Control and Serum Lipid Profile of Type 2 Diabetic Patients in University College Hospital Ibadan, Oyo State, Nigeria. Journal of Food and Nutrition Sciences, 4(4), 98-102. https://doi.org/10.11648/j.jfns.20160404.14

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ACS Style

Funmilayo Esther Omotoye; Grace Tanimoowo Fadupin. Association Between Glycaemic Control and Serum Lipid Profile of Type 2 Diabetic Patients in University College Hospital Ibadan, Oyo State, Nigeria. J. Food Nutr. Sci. 2016, 4(4), 98-102. doi: 10.11648/j.jfns.20160404.14

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AMA Style

Funmilayo Esther Omotoye, Grace Tanimoowo Fadupin. Association Between Glycaemic Control and Serum Lipid Profile of Type 2 Diabetic Patients in University College Hospital Ibadan, Oyo State, Nigeria. J Food Nutr Sci. 2016;4(4):98-102. doi: 10.11648/j.jfns.20160404.14

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@article{10.11648/j.jfns.20160404.14,
  author = {Funmilayo Esther Omotoye and Grace Tanimoowo Fadupin},
  title = {Association Between Glycaemic Control and Serum Lipid Profile of Type 2 Diabetic Patients in University College Hospital Ibadan, Oyo State, Nigeria},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {4},
  number = {4},
  pages = {98-102},
  doi = {10.11648/j.jfns.20160404.14},
  url = {https://doi.org/10.11648/j.jfns.20160404.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20160404.14},
  abstract = {Diabetes mellitus is a chronic disease that requires long term medical attention both to limit the development of its devastating complications and manage them when they occur. Lowering high blood sugar in patients with diabetes (glycaemic control) is essential to reduce their risk of complications associated with diabetes. This study was designed to assess the effect of glycaemic control on the serum lipid profile of type II diabetic patients in the university college hospital Ibadan, Oyo State. The study was descriptive cross sectional in design to assess the effect of glycaemic control on serum lipid profile of the participants. A total of 50 consenting adults, aged 40-72 years, 20 (40%) males and 30 (60%) females, type II diabetic patients were studied between March and August 2006. The demographic characteristics and dietary pattern of the participants were assessed through a semi-structured interviewer administered questionnaire and food frequency questionnaire. The serum lipids of participants for the last six months and the mean of their last four fasting blood glucose (FBG) levels were assessed from their hospital records. The effect of the glycaemic index on their lipid profile was determined using correlation coefficient and chi-square. The mean age of the respondents was 57.82±3.3 years. They were predominantly 45 (90%) Yorubas. A total of 68% had either secondary or post secondary/tertiary education. Their main source of energy was from cereals, grains and tuber crops while legumes were their major source of protein. A total of 33 (66%) had controlled (normal) fasting blood glucose while 17 (34%) did not have their FBG controlled. Only 17 (34%) had normal high density lipoprotein (HDL) cholesterol while 35 (70%) and 33 (66%) had normal low density lipoprotein (LDL) cholesterol and total cholesterol respectively. The FBG of participants had an inverse relationship with HDL but positive relationship with LDL, total cholesterol and triglyceride levels of the participants. However, the effect of FBG was only significant on triglyceride level of respondents (P=0.033) and not significant on HDL, LDL, and total cholesterol (P>0.05). Good glycemic control significantly improves dyslipidemia in type 2 diabetic patients.},
 year = {2016}
}

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