Adequacy of Transthoracic Needle Biopsy Samples in the Diagnosis of a Peripheral Lung Lesion – Comparing Success Rates of Various Imaging Modalities

Salem Alshimemeri; Hanaa Bamefleh; Shukri Loutfi; Yazeed Bindous; Azzam Khankan; Waad Almusailhi

doi:doi:10.11648/j.ijmi.20170503.11

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Adequacy of Transthoracic Needle Biopsy Samples in the Diagnosis of a Peripheral Lung Lesion – Comparing Success Rates of Various Imaging Modalities

Salem Alshimemeri, Hanaa Bamefleh, Shukri Loutfi, Yazeed Bindous, Azzam Khankan, Waad Almusailhi

Published in International Journal of Medical Imaging (Volume 5, Issue 3)

Received: 6 March 2017 Accepted: 30 March 2017 Published: 27 April 2017

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Abstract

The aim of the study was to test whether a difference in the imaging modality (CT, Fluoroscopy, or Ultrasound) would result in a higher biopsy success rate for the diagnosis of lung cancer. A total of 144 transthoracic needle biopsies performed under guidance of different imaging modalities were retrospectively reviewed at King Abdulaziz Medical city in Riyadh between 2008 and 2012. A biopsy was counted a success whenever a definitive diagnosis could be achieved. CT guided biopsies revealed 51 successes out of 86 total samples, fluoroscopy guided biopsies revealed 8 successes out of 20 total samples, while for ultrasound guided biopsies, 30 successes out of 38 biopsies gave a definitive diagnosis. Comparing CT guided biopsies vs. Fluoroscopy guided biopsies, we got a p-value of 0.1884 which is clinically insignificant, 95% Confidence Interval [-0.07628, 0.46233]. On comparison of CT guided biopsies vs. ultrasound guided biopsies the p-value was 0.05558 which is also clinically insignificant, 95% Confidence Interval [-0.38150, -0.011399]. When ultrasound guided biopsies were compared to the fluoroscopy guided biopsies a p-value of 0.007461 < 0.025 was achieved which is clinically highly significant, 95% Confidence Interval [-0.38150, -0.011399]. It was determined with 95% confidence that there is a clinically significant difference (p-value of 0.007461) between success rates of Fluoroscopy guided biopsies and ultrasound guided biopsies, but not between the other pairs of modalities. Further investigations with larger sample size are warranted to compare the efficacy of fluoroscopy and ultrasound based imaging modalities for transthoracic needle biopsy.

Published in	International Journal of Medical Imaging (Volume 5, Issue 3)
DOI	10.11648/j.ijmi.20170503.11
Page(s)	34-37
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Small-Cell Lung Cancer, Non-small Cell Lung Cancer, Computed Tomography, CT-Fluoroscopy, Ultrasound, Transthoracic Needle Aspiration, PACS

References

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APA Style

Salem Alshimemeri, Hanaa Bamefleh, Shukri Loutfi, Yazeed Bindous, Azzam Khankan, et al. (2017). Adequacy of Transthoracic Needle Biopsy Samples in the Diagnosis of a Peripheral Lung Lesion – Comparing Success Rates of Various Imaging Modalities. International Journal of Medical Imaging, 5(3), 34-37. https://doi.org/10.11648/j.ijmi.20170503.11

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ACS Style

Salem Alshimemeri; Hanaa Bamefleh; Shukri Loutfi; Yazeed Bindous; Azzam Khankan, et al. Adequacy of Transthoracic Needle Biopsy Samples in the Diagnosis of a Peripheral Lung Lesion – Comparing Success Rates of Various Imaging Modalities. Int. J. Med. Imaging 2017, 5(3), 34-37. doi: 10.11648/j.ijmi.20170503.11

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AMA Style

Salem Alshimemeri, Hanaa Bamefleh, Shukri Loutfi, Yazeed Bindous, Azzam Khankan, et al. Adequacy of Transthoracic Needle Biopsy Samples in the Diagnosis of a Peripheral Lung Lesion – Comparing Success Rates of Various Imaging Modalities. Int J Med Imaging. 2017;5(3):34-37. doi: 10.11648/j.ijmi.20170503.11

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@article{10.11648/j.ijmi.20170503.11,
  author = {Salem Alshimemeri and Hanaa Bamefleh and Shukri Loutfi and Yazeed Bindous and Azzam Khankan and Waad Almusailhi},
  title = {Adequacy of Transthoracic Needle Biopsy Samples in the Diagnosis of a Peripheral Lung Lesion – Comparing Success Rates of Various Imaging Modalities},
  journal = {International Journal of Medical Imaging},
  volume = {5},
  number = {3},
  pages = {34-37},
  doi = {10.11648/j.ijmi.20170503.11},
  url = {https://doi.org/10.11648/j.ijmi.20170503.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20170503.11},
  abstract = {The aim of the study was to test whether a difference in the imaging modality (CT, Fluoroscopy, or Ultrasound) would result in a higher biopsy success rate for the diagnosis of lung cancer. A total of 144 transthoracic needle biopsies performed under guidance of different imaging modalities were retrospectively reviewed at King Abdulaziz Medical city in Riyadh between 2008 and 2012. A biopsy was counted a success whenever a definitive diagnosis could be achieved. CT guided biopsies revealed 51 successes out of 86 total samples, fluoroscopy guided biopsies revealed 8 successes out of 20 total samples, while for ultrasound guided biopsies, 30 successes out of 38 biopsies gave a definitive diagnosis. Comparing CT guided biopsies vs. Fluoroscopy guided biopsies, we got a p-value of 0.1884 which is clinically insignificant, 95% Confidence Interval [-0.07628, 0.46233]. On comparison of CT guided biopsies vs. ultrasound guided biopsies the p-value was 0.05558 which is also clinically insignificant, 95% Confidence Interval [-0.38150, -0.011399]. When ultrasound guided biopsies were compared to the fluoroscopy guided biopsies a p-value of 0.007461 < 0.025 was achieved which is clinically highly significant, 95% Confidence Interval [-0.38150, -0.011399]. It was determined with 95% confidence that there is a clinically significant difference (p-value of 0.007461) between success rates of Fluoroscopy guided biopsies and ultrasound guided biopsies, but not between the other pairs of modalities. Further investigations with larger sample size are warranted to compare the efficacy of fluoroscopy and ultrasound based imaging modalities for transthoracic needle biopsy.},
 year = {2017}
}

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TY  - JOUR
T1  - Adequacy of Transthoracic Needle Biopsy Samples in the Diagnosis of a Peripheral Lung Lesion – Comparing Success Rates of Various Imaging Modalities
AU  - Salem Alshimemeri
AU  - Hanaa Bamefleh
AU  - Shukri Loutfi
AU  - Yazeed Bindous
AU  - Azzam Khankan
AU  - Waad Almusailhi
Y1  - 2017/04/27
PY  - 2017
N1  - https://doi.org/10.11648/j.ijmi.20170503.11
DO  - 10.11648/j.ijmi.20170503.11
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 34
EP  - 37
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20170503.11
AB  - The aim of the study was to test whether a difference in the imaging modality (CT, Fluoroscopy, or Ultrasound) would result in a higher biopsy success rate for the diagnosis of lung cancer. A total of 144 transthoracic needle biopsies performed under guidance of different imaging modalities were retrospectively reviewed at King Abdulaziz Medical city in Riyadh between 2008 and 2012. A biopsy was counted a success whenever a definitive diagnosis could be achieved. CT guided biopsies revealed 51 successes out of 86 total samples, fluoroscopy guided biopsies revealed 8 successes out of 20 total samples, while for ultrasound guided biopsies, 30 successes out of 38 biopsies gave a definitive diagnosis. Comparing CT guided biopsies vs. Fluoroscopy guided biopsies, we got a p-value of 0.1884 which is clinically insignificant, 95% Confidence Interval [-0.07628, 0.46233]. On comparison of CT guided biopsies vs. ultrasound guided biopsies the p-value was 0.05558 which is also clinically insignificant, 95% Confidence Interval [-0.38150, -0.011399]. When ultrasound guided biopsies were compared to the fluoroscopy guided biopsies a p-value of 0.007461 < 0.025 was achieved which is clinically highly significant, 95% Confidence Interval [-0.38150, -0.011399]. It was determined with 95% confidence that there is a clinically significant difference (p-value of 0.007461) between success rates of Fluoroscopy guided biopsies and ultrasound guided biopsies, but not between the other pairs of modalities. Further investigations with larger sample size are warranted to compare the efficacy of fluoroscopy and ultrasound based imaging modalities for transthoracic needle biopsy.
VL  - 5
IS  - 3
ER  -

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Author Information

Salem Alshimemeri

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia
Hanaa Bamefleh

Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
Shukri Loutfi

Department of Medical Imaging, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
Yazeed Bindous

Department of Medical Imaging, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
Azzam Khankan

Department of Medical Imaging, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
Waad Almusailhi

College of Medicine, Almaarefa Colleges for Science and Technology, Riyadh, Kingdom of Saudi Arabia

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APA Style

Salem Alshimemeri, Hanaa Bamefleh, Shukri Loutfi, Yazeed Bindous, Azzam Khankan, et al. (2017). Adequacy of Transthoracic Needle Biopsy Samples in the Diagnosis of a Peripheral Lung Lesion – Comparing Success Rates of Various Imaging Modalities. International Journal of Medical Imaging, 5(3), 34-37. https://doi.org/10.11648/j.ijmi.20170503.11

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ACS Style

Salem Alshimemeri; Hanaa Bamefleh; Shukri Loutfi; Yazeed Bindous; Azzam Khankan, et al. Adequacy of Transthoracic Needle Biopsy Samples in the Diagnosis of a Peripheral Lung Lesion – Comparing Success Rates of Various Imaging Modalities. Int. J. Med. Imaging 2017, 5(3), 34-37. doi: 10.11648/j.ijmi.20170503.11

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AMA Style

Salem Alshimemeri, Hanaa Bamefleh, Shukri Loutfi, Yazeed Bindous, Azzam Khankan, et al. Adequacy of Transthoracic Needle Biopsy Samples in the Diagnosis of a Peripheral Lung Lesion – Comparing Success Rates of Various Imaging Modalities. Int J Med Imaging. 2017;5(3):34-37. doi: 10.11648/j.ijmi.20170503.11

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@article{10.11648/j.ijmi.20170503.11,
  author = {Salem Alshimemeri and Hanaa Bamefleh and Shukri Loutfi and Yazeed Bindous and Azzam Khankan and Waad Almusailhi},
  title = {Adequacy of Transthoracic Needle Biopsy Samples in the Diagnosis of a Peripheral Lung Lesion – Comparing Success Rates of Various Imaging Modalities},
  journal = {International Journal of Medical Imaging},
  volume = {5},
  number = {3},
  pages = {34-37},
  doi = {10.11648/j.ijmi.20170503.11},
  url = {https://doi.org/10.11648/j.ijmi.20170503.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20170503.11},
  abstract = {The aim of the study was to test whether a difference in the imaging modality (CT, Fluoroscopy, or Ultrasound) would result in a higher biopsy success rate for the diagnosis of lung cancer. A total of 144 transthoracic needle biopsies performed under guidance of different imaging modalities were retrospectively reviewed at King Abdulaziz Medical city in Riyadh between 2008 and 2012. A biopsy was counted a success whenever a definitive diagnosis could be achieved. CT guided biopsies revealed 51 successes out of 86 total samples, fluoroscopy guided biopsies revealed 8 successes out of 20 total samples, while for ultrasound guided biopsies, 30 successes out of 38 biopsies gave a definitive diagnosis. Comparing CT guided biopsies vs. Fluoroscopy guided biopsies, we got a p-value of 0.1884 which is clinically insignificant, 95% Confidence Interval [-0.07628, 0.46233]. On comparison of CT guided biopsies vs. ultrasound guided biopsies the p-value was 0.05558 which is also clinically insignificant, 95% Confidence Interval [-0.38150, -0.011399]. When ultrasound guided biopsies were compared to the fluoroscopy guided biopsies a p-value of 0.007461 < 0.025 was achieved which is clinically highly significant, 95% Confidence Interval [-0.38150, -0.011399]. It was determined with 95% confidence that there is a clinically significant difference (p-value of 0.007461) between success rates of Fluoroscopy guided biopsies and ultrasound guided biopsies, but not between the other pairs of modalities. Further investigations with larger sample size are warranted to compare the efficacy of fluoroscopy and ultrasound based imaging modalities for transthoracic needle biopsy.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Adequacy of Transthoracic Needle Biopsy Samples in the Diagnosis of a Peripheral Lung Lesion – Comparing Success Rates of Various Imaging Modalities
AU  - Salem Alshimemeri
AU  - Hanaa Bamefleh
AU  - Shukri Loutfi
AU  - Yazeed Bindous
AU  - Azzam Khankan
AU  - Waad Almusailhi
Y1  - 2017/04/27
PY  - 2017
N1  - https://doi.org/10.11648/j.ijmi.20170503.11
DO  - 10.11648/j.ijmi.20170503.11
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 34
EP  - 37
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20170503.11
AB  - The aim of the study was to test whether a difference in the imaging modality (CT, Fluoroscopy, or Ultrasound) would result in a higher biopsy success rate for the diagnosis of lung cancer. A total of 144 transthoracic needle biopsies performed under guidance of different imaging modalities were retrospectively reviewed at King Abdulaziz Medical city in Riyadh between 2008 and 2012. A biopsy was counted a success whenever a definitive diagnosis could be achieved. CT guided biopsies revealed 51 successes out of 86 total samples, fluoroscopy guided biopsies revealed 8 successes out of 20 total samples, while for ultrasound guided biopsies, 30 successes out of 38 biopsies gave a definitive diagnosis. Comparing CT guided biopsies vs. Fluoroscopy guided biopsies, we got a p-value of 0.1884 which is clinically insignificant, 95% Confidence Interval [-0.07628, 0.46233]. On comparison of CT guided biopsies vs. ultrasound guided biopsies the p-value was 0.05558 which is also clinically insignificant, 95% Confidence Interval [-0.38150, -0.011399]. When ultrasound guided biopsies were compared to the fluoroscopy guided biopsies a p-value of 0.007461 < 0.025 was achieved which is clinically highly significant, 95% Confidence Interval [-0.38150, -0.011399]. It was determined with 95% confidence that there is a clinically significant difference (p-value of 0.007461) between success rates of Fluoroscopy guided biopsies and ultrasound guided biopsies, but not between the other pairs of modalities. Further investigations with larger sample size are warranted to compare the efficacy of fluoroscopy and ultrasound based imaging modalities for transthoracic needle biopsy.
VL  - 5
IS  - 3
ER  -

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